A train derailed in the Portuguese district of Coimbra, killing two and injuring at least 37 others.
The train was travelling north when it collided with a railway maintenance machine in the town of Soure.
Mayor of Soure Mário Jorge told Portuguese media that the crash happened at about 15:30.
The country’s national relief operations authority CNOS was deployed at the scene.
A CNOS spokesman said there were 163 rescue personnel, including firefighters, and two medical helicopters.
There were 240 passengers on board the Alfa Pendular train, which is the fastest in Portugal, CNOS spokesman added.
A field hospital is also reportedly being set up nearby.
According to local media, several people remain trapped on the train.