36-year-old Reynhard Sinaga was jailed for life after he was convicted of 159 sex offences, including 136 rapes.
It will “never be safe to be released”, a judge said.
Sinaga was found guilty of luring 48 men from outside Manchester clubs to his flat, where he drugged and assaulted them.
The Crown Prosecution Service (CPS) said Sinaga was “the most prolific rapist in British legal history”.
The judge ruled his life sentence must include a minimum of 30 years in jail.
The post-graduate student was already serving life, with a minimum term of 20 years, for the offences he was convicted of in two earlier trials, which took place in summer 2018 and last spring.
Across four separate trials, the Indonesian national was found guilty of 136 counts of rape, eight counts of attempted rape, 14 counts of sexual assault, against a total of 48 victims.
At the hearing, Judge Suzanne Goddard QC said Sinaga was “an evil serial sexual predator who has preyed upon young men” who wanted “nothing more than a good night out with their friends”.
“In my judgment you are a highly dangerous, cunning and deceitful individual who will never be safe to be released,” she said – adding that the decision to release prisoners is made by the Parole Board.
Sinaga would wait for men leaving nightclubs and bars before leading them to his flat in Montana House, Princess Street, often with the offer of somewhere to have a drink or call a taxi.
He drugged his victims before assaulting them while they were unconscious. When the victims woke up many of them had no memory of what had happened.
Home Secretary Priti Patel said she was “deeply concerned” by the use of drugs.
Sinaga, who was studying for a PHD at the University of Leeds, carried out his attacks over several years.
The rapist was caught in June 2017 when one victim, who regained consciousness while being assaulted, fought Sinaga off and called the police.
When officers seized Sinaga’s phone they found he had filmed each of his attacks. The discovery led to the launch of the largest rape inquiry in British history.