The Australian annual F1 Grand Prix for the second year in a row because of the coronavirus pandemic.
The Australian round of the MotoGP world championship, scheduled for 24 October was also cancelled.
The Formula 1 event was due to take place from 19-21 November but has been abandoned because of tight border controls in Australia.
Australian Grand Prix Corporation chairman Paul Little said he was “deeply disappointed” in a statement.
“We appreciate the challenge Australia faces with current international travel restrictions and the importance of vaccinations,” he added.
The Australian Grand Prix was called off in 2020 and put in place to open the current season on 14 March, only for the date to be moved to November because of border controls.
Its November date race was only to be followed by two more in the F1 season in Saudi Arabia and Abu Dhabi.
Currently Australian border rules require visitors to quarantine for 14 days, a condition of entry expected to be in place until at least the end of the year.
Organisers of the event ultimately cited “restrictions and logistical challenges relating to the ongoing Covid-19 pandemic,” for the cancellation.
Formula 1 chief Stefano Domenicali said a 23-race season would still be possible despite the cancellation.
“While it is disappointing we won’t be racing in Australia this season, we are confident we can deliver a 23-race season in 2021 and we have a number of options to take forward,” he said.
The Australian round of the MotoGP world championship, scheduled to take place at Phillip Island, has also now been wiped out for a second successive year.
The event organisers said: “The ongoing pandemic and resulting travel complications and logistical restrictions mean it has not been possible to confirm the viability of the event at this time, and it will therefore not feature on the 2021 calendar.”
The Malaysia MotoGP has been brought forward to take place from 22-24 October, the original dates of the Australia event.