The violence between Israel and Palestine intensified on Monday after the Israeli military launched airstrikes targeting the Gaza Strip.
Palestinians also fired rockets towards Jerusalem.
Palestinian health officials in Gaza said 20 people, including children, had died in the strikes. Israel’s military said at least three members of the Hamas group that rules Gaza were among those killed.
The Hamas has threatened to retaliate after hundreds of Palestinians were injured in attacks by Israeli police at the holy site in Jerusalem over the past few days.
Israel’s caretaker Prime Minister Benjamin Netanyahu, who faces corruption charges said Hamas had “crossed a red line” and that Israel would respond “with great force”.
The past few days have seen the worst violence in Jerusalem in years.
Palestinians have been angered about restrictions on access to the compound, where the al-Aqsa mosque, the third holiest site in Islam is housed.
On Tuesday, the Palestinian Red Crescent, a humanitarian group, said more than 700 Palestinians had been injured in clashes with Israeli security forces in Jerusalem and across the West Bank.
Countries worldwide have appealed for calm. The US, the European Union and the UK have urged Israel and the Palestinians to lower tensions.